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Readings

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Required Textbooks

Weiss, Thomas F. Cellular Biophysics: Transport. Vol. 1. Cambridge, MA: MIT Press, 1995. ISBN: 0262231832.

———. Cellular Biophysics: Electrical Properties. Vol. 2. Cambridge, MA: MIT Press, 1996. ISBN: 0262231840.


ses # Topics READINGS
L1 Introduction to Cellular Transport
R1 Review of Differential Equations
L2 Macroscopic and Microscopic Laws of Diffusion Weiss. Volume 1: 3.1-3.1.3, 3.2-3.2.2.
L3 Continuity and Diffusion Equations Weiss. Volume 1: 3.1.4-3.1.5, 3.5-3.5.2.1.
R2 Diffusion
L4 Diffusion in Cells: Models Weiss. Volume 1: 3.6-3.6.1.2, 3.7-3.7.2.
R3 Diffusion (cont.)
L5 Diffusion in Cells: Experiments Weiss. Volume 1: 3.8-3.8.5.
L6 Osmosis: van Hoff's Law Weiss. Volume 1: 4.1-4.3.2.3, 4.4-4.5.1.2.
R4 Diffusion and Osmosis
L7 Osmosis in Cells: Equilibrium Weiss. Volume 1: 4.7-4.7.1.2.
R5 Osmosis
L8 Chemical Transport Weiss. Volume 1: 4.7.2-Fig. 4.26 (p. 230), Fig. 4.28, 4.8.2-4.8.3, 6.1-6.2.1.4.
L9 Four-State Symmetric Carrier Model Weiss. Volume 1: 6.4-6.4.1.4.
R6 Osmosis and Carrier Mediated Transport
L10 Carrier Models Weiss. Volume 1: 6.4.2-6.4.3, 6.6-6.7.4.
R7 4-State Model
L11 Glucose Regulation Weiss. Volume 1: 7.2.1, 7.2.3, 7.2.4.1, 7.4.
L12 Ion Transport: Nernst-Planck Equation
R8 Carrier Models
L13 Writing a Laboratory Report
Exam 1
L14 Ion Transport: Models
R9 Ions
L15 Ion Transport Models (cont.) Weiss. Volume 1: 7.5.
R10 Ions (cont.)
L16 Active Transport Weiss. Volume 1: 7.5.
L17 Electrical Properties of Cells Weiss. Volume 2: Chapter 1.
Writing Clinic
L18 Core Conductor Model of Large Cells Weiss. Volume 2: 2.1-2.4.2.
R11 Core Conductor
L19 Core Conductor Weiss. Volume 2: 2.4.3-2.5.
L20 HH: Space Clamp Weiss. Volume 2: 4.1-4.1.2.3, 4.2-4.2.2.2.
R12 Core Conductor (cont.)
L21 HH: Voltage Clamp Weiss. Volume 2: 4.2.3-4.2.3.1.
R13 Core Conductor (cont.)
L22 HH: Current Clamp Weiss. Volume 2: 4.2.3-4.2.3.2.
L23 Demo: HH Project Weiss. Volume 2: 4.3.
R14 HH Elec Classroom
L24 HH Project Weiss. Volume 2: 4.4.8.
Exam 2
L25 HH: Threshold Weiss. Volume 2: 4.4.1.
L26 Cable Model Weiss. Volume 2: 3.1-3.2.1, 3.3-3.4.2.1.
R15 HH Elec Classroom (cont.)
L27 Cable Model (cont.)
L28 Writing an Oral Presentation Weiss. Volume 2: 3.4.2.4-3.4.3.1, 3.4.3.3-3.5.
L29 Myelinated Fibers Weiss. Volume 2: 5.1-5.2.4.4.
R16 Cable Model
L30 Saltatory Conduction Weiss. Volume 2: 5.3-5.7.
R17 Saltatory Conduction
L31 Patch Clamp Weiss. Volume 2: 6.1-6.1.1, 6.4-6.4.1.5, 6.2-6.2.2, 6.5-p. 407.
L32 Ion Channels: 2-State Models Weiss. Volume 2: 6.5-p. 407.
HH Dry Runs
L33 Ion Channels: 4 Gate Model Weiss. Volume 2: p. 407-p. 416.
L34 Ion Channels: Gating Currents Weiss. Volume 2: 6.3.2-6.3.6.
R18 Ion Channels
R19 Ion Channels (cont.)
L35 Ion Channels Multi-State Models Weiss. Volume 2: 6.6, 6.7.
R20 Ion Channels (cont.)
L36 Breakfast with the Staff
R21 Ion Channels (cont.)
Final Exam Period